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Pentoxifylline downregulates profibrogenic cytokines and procollagen I expression in rat secondary biliary fibrosis.

Authors
  • Raetsch, C1
  • Jia, J D
  • Boigk, G
  • Bauer, M
  • Hahn, E G
  • Riecken, E-O
  • Schuppan, D
  • 1 Department of Gastroenterology, University Hospital Benjamin Franklin, Free University of Berlin, Germany.
Type
Published Article
Journal
Gut
Publication Date
February 2002
Volume
50
Issue
2
Pages
241–247
Identifiers
PMID: 11788567
Source
Medline
License
Unknown

Abstract

We conclude that targeting pentoxifylline to the fibrogenic cells, thereby avoiding upregulation of TIMP-1, could become a potent antifibrogenic tool in chronic liver disease.

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