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Pentamidine Congeners 1: Synthesis of Cis- and Trans-Butamidine Analogues As Anti-Pneumocystis carinii Pneumonia Agents.

Authors
  • Donkor, Isaac O1
  • Jones, Susan K
  • Tidwell, Richard R
  • 1 College of Pharmacy, Xavier University of Louisiana, New Orleans, LA 70125.
Type
Published Article
Journal
Bioorganic & medicinal chemistry letters
Publication Date
Jan 01, 1993
Volume
3
Issue
6
Pages
1137–1140
Identifiers
PMID: 21451734
Source
Medline
License
Unknown

Abstract

Butamidine analogues possessing unsaturation in the ether bridge between the bisamidinophenyl or bisimidazolinophenyl functionalities have been synthesized as semirigid congeners of pentamidine. These compounds demonstrated good anti-P. carinii pueumonia activity in a rat model of the disease.

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