Pentamidine Congeners 1: Synthesis of Cis- and Trans-Butamidine Analogues As Anti-Pneumocystis carinii Pneumonia Agents.
College of Pharmacy, Xavier University of Louisiana, New Orleans, LA 70125.
- Published Article
Bioorganic & medicinal chemistry letters
- Publication Date
Jan 01, 1993
Butamidine analogues possessing unsaturation in the ether bridge between the bisamidinophenyl or bisimidazolinophenyl functionalities have been synthesized as semirigid congeners of pentamidine. These compounds demonstrated good anti-P. carinii pueumonia activity in a rat model of the disease.
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The corresponding record at NLM can be accessed at https://www.ncbi.nlm.nih.gov/pubmed/21451734