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Penetration of doxycycline into cerebrospinal fluid in patients treated for suspected Lyme neuroborreliosis.

Authors
  • Dotevall, L
  • Hagberg, L
Type
Published Article
Journal
Antimicrobial agents and chemotherapy
Publication Date
Jul 01, 1989
Volume
33
Issue
7
Pages
1078–1080
Identifiers
PMID: 2782858
Source
Medline
License
Unknown

Abstract

Twelve patients were treated orally with 100 mg of doxycycline twice a day (b.i.d.) and 10 patients were treated with 200 mg b.i.d. for suspected tick-borne neuroborreliosis (Lyme borreliosis). At 5 to 8 days after the start of therapy, the mean concentrations in serum were 4.7 micrograms/ml for the doxycycline dose of 100 mg b.i.d. and 7.5 micrograms/ml for 200 mg b.i.d., 2 to 3 h after the last drug administration. The corresponding levels for cerebrospinal fluid were 0.6 and 1.1 micrograms/ml. Since a doxycycline concentration in cerebrospinal fluid above the estimated MIC for Borrelia burgdorferi (0.6 to 0.7 microgram/ml) is wanted in patients treated for severe neuroborreliosis, the higher dose is preferable.

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