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Penetration of amphotericin B lipid formulations into pleural effusion.

Authors
  • Weiler, Stefan
  • Bellmann-Weiler, Rosa
  • Joannidis, Michael
  • Bellmann, Romuald
Type
Published Article
Journal
Antimicrobial agents and chemotherapy
Publication Date
Nov 01, 2007
Volume
51
Issue
11
Pages
4211–4213
Identifiers
PMID: 17785511
Source
Medline
License
Unknown

Abstract

The penetration of the amphotericin B (AMB) lipid formulations (liposomal AMB, AMB colloidal dispersion, and AMB lipid complex formulations) into pleural effusions in seven critically ill patients was assessed. AMB was detected in all pleural effusion samples at concentrations ranging from 0.02 to 0.43 microg/ml. The penetration ratio was 3 to 44%.

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