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PEGylated polyethylenimine-stabilized polypyrrole nanoparticles loaded with DOX for chemo-photothermal therapy of cancer cells

Authors
  • Lan, Shuhang1, 2
  • Xie, Weicheng1, 2
  • Wang, Jingjing1
  • Hu, Jie1
  • Tang, Wei1
  • Yang, Wenting1
  • Yu, Xiangrong3
  • Liu, Hui1, 2
  • 1 Southwest University, Key Laboratory of Luminescent and Real-Time Analytical Chemistry (Southwest University), Ministry of Education, Faculty of Materials and Energy, Chongqing, 400715, China , Chongqing (China)
  • 2 Chongqing Engineering Research Center for Micro-Nano Biomedical Materials and Devices, Chongqing, 400715, China , Chongqing (China)
  • 3 Zhuhai Hospital of Jinan University, Zhuhai People’s Hospital, Department of Radiology, 79 Kangning Road, Zhuhai, Guangdong, 519000, People’s Republic of China , Zhuhai (China)
Type
Published Article
Journal
Journal of Nanoparticle Research
Publisher
Springer-Verlag
Publication Date
Nov 10, 2018
Volume
20
Issue
11
Identifiers
DOI: 10.1007/s11051-018-4418-9
Source
Springer Nature
Keywords
License
Yellow

Abstract

Combination of kinds of therapy modalities is promising for effective cancer treatment. Herein, a kind of multifunctional nanoparticles (NPs) was developed for cancer chemo-photothermal therapy applications. Polypyrrole (PPy) NPs were formed using a facile polymerization method using poly(ethyleneimine) (PEI) as stabilizer, followed by polyethylene glycol (PEG) modification and anticancer drug doxorubicin (DOX) loading. Showing obvious absorbance in the NIR range, the obtained PPy-PEI-PEG NPs displayed well photothermal ability with desirable photothermal stability. The release of the loaded DOX can be promoted by pH and laser stimulation. Compared with single therapy modality, the combination of chemotherapy and photothermal therapy showed higher cancer cell killing effect. The cellular internalization of the obtained NPs was proved to be effective. The developed multifunctional NPs are promising candidates for combined therapy of cancer cells.

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