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PD-L1 is increased in the spinal cord and infiltrating lymphocytes in experimental allergic encephalomyelitis.

Authors
  • Li, Min1
  • Jiang, Jiandong1
  • Fu, Bing1
  • Chen, Jiechun1
  • Xue, Qun2
  • Dong, Wanli2
  • Gu, Yanzheng3
  • Tang, Lingtao4
  • Xue, Limin5
  • Fang, Qi5
  • Wang, Mingyuan6
  • Zhang, Xueguang3
  • 1 Department of Neurology, Second People's Hospital of Lianyungang City, Lianyungang 222006, Jiangsu Province, China. , (China)
  • 2 Department of Neurology, First Affiliated Hospital of Soochow University, Suzhou 215006, Jiangsu Province, China ; Institute of Clinical Immunology, Soochow University, Suzhou 215006, Jiangsu Province, China. , (China)
  • 3 Institute of Clinical Immunology, Soochow University, Suzhou 215006, Jiangsu Province, China. , (China)
  • 4 Department of Neurology, Third Hospital of Xingtai City, Xingtai 054000, Hebei Province, China. , (China)
  • 5 Department of Neurology, First Affiliated Hospital of Soochow University, Suzhou 215006, Jiangsu Province, China. , (China)
  • 6 Red-Cross Blood Center of Suzhou City, Suzhou 215006, Jiangsu Province, China. , (China)
Type
Published Article
Journal
Neural Regeneration Research
Publisher
Medknow Publications
Publication Date
Dec 15, 2013
Volume
8
Issue
35
Pages
3296–3305
Identifiers
DOI: 10.3969/j.issn.1673-5374.2013.35.004
PMID: 25206651
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Experimental allergic encephalomyelitis is a mouse model of human multiple sclerosis with similar pathology and pathogenesis. Th1 cells play an important role in the pathogenesis of experimental allergic encephalomyelitis. This study determined the potential effect of programmed cell death 1 ligand 1 in the pathogenesis of experimental allergic encephalomyelitis induced by injecting myelin oligodendrocyte glycoprotein, complete Freund's adjuvant and Bordetella pertussis toxin into C57BL/6J mice. Experimental allergic encephalomyelitis mice developed disease and showed inflammatory changes in the central nervous system by hematoxylin-eosin staining of spinal cord pathological sections, demyelination by Luxol fast-blue staining and clinical manifestations. The expression of programmed cell death 1 ligand 1 in mice was detected by immunohistochemistry, flow cytometry and western blot analysis. The expression of programmed cell death 1 ligand 1 in the spinal cord and splenocytes of mice was significantly increased compared with normal mice. Our findings suggest the involvement of programmed cell death 1 ligand 1 in the pathogenesis of experimental allergic encephalomyelitis and suggest this should be studied in multiple sclerosis.

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