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PDGF- and TGF-beta-induced changes in cell shape of invertebrate immunocytes: effect of calcium entry blockers.

Authors
  • Ottaviani, E
  • Sassi, D
  • Kletsas, D
Type
Published Article
Journal
European Journal of Cell Biology
Publisher
Elsevier
Publication Date
Dec 01, 1997
Volume
74
Issue
4
Pages
336–341
Identifiers
PMID: 9438129
Source
Medline
License
Unknown

Abstract

The cellular activity of hemocytes from the marine mollusc Mytilus galloprovincialis was studied using computer-assisted microscopic image analysis. PDGF-AB and TGF-beta 1 caused changes in cellular shape and induced the immunocytes to migrate in a chemotactic manner. The effect of PDGF-AB was more potent than that of TGF-beta 1, and the responses were dose-correlated for PDGF-AB, while they were dose-dependent up to 5 pg/ml for TGF-beta 1. Moreover, the PDGF-AB response was extracellular Ca(2+)-independent, while TGF-beta 1 was Ca(2+)-dependent.

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