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The PDE4 inhibitor rolipram reverses object memory impairment induced by acute tryptophan depletion in the rat.

Authors
Type
Published Article
Journal
Psychopharmacology
Publication Date
Volume
192
Issue
2
Pages
275–282
Identifiers
PMID: 17265077
Source
Medline
License
Unknown

Abstract

On the basis of previous studies and the ability to reverse a serotonergic deficit, we suggest that rolipram may act through elevation of cyclic adenosine monophosphate levels and subsequent increase in neurotransmitter release.

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