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PD-1-Expressing SARS-CoV-2-Specific CD8 + T Cells Are Not Exhausted, but Functional in Patients with COVID-19

Authors
  • Rha, Min-Seok1
  • Jeong, Hye Won2
  • Ko, Jae-Hoon3
  • Choi, Seong Jin1
  • Seo, In-Ho1
  • Lee, Jeong Seok1, 4
  • Sa, Moa1, 5
  • Kim, A Reum1
  • Joo, Eun-Jeong6
  • Ahn, Jin Young7
  • Kim, Jung Ho7
  • Song, Kyoung-Ho8
  • Kim, Eu Suk8
  • Oh, Dong Hyun9
  • Ahn, Mi Young9
  • Choi, Hee Kyoung10
  • Jeon, Ji Hoon10
  • Choi, Jae-Phil9
  • Kim, Hong Bin8
  • Kim, Young Keun11
  • And 5 more
  • 1 Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, Republic of Korea
  • 2 Department of Internal Medicine, Chungbuk National University College of Medicine, Cheongju 28644, Republic of Korea
  • 3 Division of Infectious Diseases, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 06351, Republic of Korea
  • 4 GENOME INSIGHT Inc., Daejeon 34051, Republic of Korea
  • 5 The Center for Epidemic Preparedness, KAIST Institute, Daejeon 34141, Republic of Korea
  • 6 Division of Infectious Diseases, Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul 03181, Republic of Korea
  • 7 Department of Internal Medicine, Severance Hospital, Yonsei University College of Medicine, Seoul 03722, Republic of Korea
  • 8 Department of Internal Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam 13620, Republic of Korea
  • 9 Department of Internal Medicine, Seoul Medical Center, Seoul 02053, Republic of Korea
  • 10 Division of Infectious Diseases, Department of Internal Medicine, Korea University College of Medicine, Ansan Hospital, Ansan 15355, Republic of Korea
  • 11 Department of Internal Medicine, Wonju Severance Christian Hospital, Yonsei University Wonju College of Medicine, Wonju 26426, Republic of Korea
Type
Published Article
Journal
Immunity
Publication Date
Dec 14, 2020
Volume
54
Issue
1
Pages
44–52
Identifiers
DOI: 10.1016/j.immuni.2020.12.002
PMID: 33338412
PMCID: PMC7834198
Source
PubMed Central
Keywords
Disciplines
  • Report
License
Unknown

Abstract

T cell responses have been demonstrated in COVID-19 patients, but ex vivo phenotypes and functions of SARS-CoV-2-specific T cells remain unclear. Rha et al. examined SARS-CoV-2-specific CD8+ T cells in acute and convalescent COVID-19 patients using MHC class I multimers, finding that PD-1-expressing SARS-CoV-2-specific CD8+ T cells are not exhausted but functional.

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