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Pd-catalyzed aldehyde to ester conversion: a hydrogen transfer approach.

Authors
  • Tschaen, Brittany A
  • Schmink, Jason R
  • Molander, Gary A
Type
Published Article
Journal
Organic Letters
Publisher
American Chemical Society
Publication Date
Feb 01, 2013
Volume
15
Issue
3
Pages
500–503
Identifiers
DOI: 10.1021/ol303298g
PMID: 23320580
Source
Medline
License
Unknown

Abstract

Aliphatic and aromatic aldehydes are successfully converted into their corresponding esters using Pd(OAc)(2) and XPhos. This approach utilizes a hydrogen transfer protocol: concomitant reduction of acetone to isopropanol provides an inexpensive and sustainable approach that mitigates the need for other oxidants.

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