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PD 116,152, a new phenazine antitumor antibiotic. Structure and antitumor activity.

Authors
  • Smitka, T A
  • Bunge, R H
  • Wilton, J H
  • Hokanson, G C
  • French, J C
  • He, C H
  • Clardy, J
Type
Published Article
Journal
The Journal of antibiotics
Publication Date
Jun 01, 1986
Volume
39
Issue
6
Pages
800–803
Identifiers
PMID: 3755428
Source
Medline
License
Unknown

Abstract

A new, highly substituted phenazine with antitumor activity was isolated from the culture broth of a Streptomyces sp. This compound, whose structure was determined by spectroscopic methods and verified by X-ray diffraction analysis, was found to be methyl 6-formyl-4,7,9-trihydroxy-8-methyl-1-phenazinecarboxylate.

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