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Patterns of retention of particulate matter in lung tissues of patients with COPD: potential role in disease progression.

Authors
  • Ling, Sean H1
  • McDonough, John E1
  • Gosselink, John V1
  • Elliott, W Mark1
  • Hayashi, Shizu1
  • Hogg, James C1
  • van Eeden, Stephan F2
  • 1 UBC James Hogg Research Centre, Heart and Lung Institute, St. Paul's Hospital, University of British Columbia, Vancouver, BC, Canada. , (Canada)
  • 2 UBC James Hogg Research Centre, Heart and Lung Institute, St. Paul's Hospital, University of British Columbia, Vancouver, BC, Canada. Electronic address: [email protected] , (Canada)
Type
Published Article
Journal
CHEST Journal
Publisher
Elsevier
Publication Date
December 2011
Volume
140
Issue
6
Pages
1540–1549
Identifiers
DOI: 10.1378/chest.10-2281
PMID: 21659433
Source
Medline
License
Unknown

Abstract

We conclude that retained PM is widely distributed in lung tissues of subjects with COPD and that cigarette smoke exposure and airflow obstruction are associated with retention of PM in lung tissues. We attribute the downward trend in PM burden in severe COPD to either less deposition and retention or selective removal of PM containing tissues by emphysematous destruction.

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