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Patterns of neoplasia in c-mos transgenic mice and their relevance to multiple endocrine neoplasia.

Authors
  • Schulz, N
  • Propst, F
  • Rosenberg, M M
  • Linnoila, R I
  • Paules, R S
  • Schulte, D
  • Vande Woude, G F
Type
Published Article
Journal
Henry Ford Hospital medical journal
Publication Date
Jan 01, 1992
Volume
40
Issue
3-4
Pages
307–311
Identifiers
PMID: 1362427
Source
Medline
License
Unknown

Abstract

We have previously described a neurological phenotype for transgenic mice carrying the c-Mos proto-oncogene. Pheochromocytomas and C-cell thyroid neoplasms occur in these transgenic lines in patterns that are similar to those seen in multiple endocrine neoplasia type 2 (MEN 2). Characterization of the pathological lesions via immunohistochemistry underscores similarities between MEN 2 and these transgenic mice. When transgenic mice that do not display the MEN 2 phenotype are crossed to a different background, the progeny display the MEN 2 phenotype. Thus the interaction of the background with the transgene is such that it can suppress tumor information. This observation bears special relevance to the human syndrome in that this model system may be used to study the question of penetrance of phenotype.

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