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Patterns of mitochondrial DNA damage in blood and brain tissues of a transgenic mouse model of Machado-Joseph disease.

Authors
  • Kazachkova, Nadiya
  • Raposo, Mafalda
  • Montiel, Rafael
  • Cymbron, Teresa
  • Bettencourt, Conceição
  • Silva-Fernandes, Anabela
  • Silva, Sara
  • Maciel, Patrícia
  • Lima, Manuela
Type
Published Article
Journal
Neuro-degenerative diseases
Publication Date
Jan 01, 2013
Volume
11
Issue
4
Pages
206–214
Identifiers
DOI: 10.1159/000339207
PMID: 22832131
Source
Medline
License
Unknown

Abstract

These results suggest that mtDNA damage is related to the initiation of the phenotype in transgenic mice; mtDNA 3,867-bp deletions may be a biomarker of the initial stages of the disease.

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