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Patterns of atrophy in pathologically confirmed dementias: a voxelwise analysis.

Authors
  • Harper, Lorna1
  • Bouwman, Femke2
  • Burton, Emma J3
  • Barkhof, Frederik4, 5, 6
  • Scheltens, Philip2
  • O'Brien, John T7
  • Fox, Nick C1
  • Ridgway, Gerard R8, 9
  • Schott, Jonathan M1
  • 1 Dementia Research Centre, University College London Institute of Neurology, London, UK.
  • 2 Alzheimer Centre, VU University Medical Centre, Amsterdam, The Netherlands. , (Netherlands)
  • 3 Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, UK.
  • 4 Department of Radiology and Nuclear Medicine, VU Medical Center, MS Center, Amsterdam, The Netherlands. , (Netherlands)
  • 5 Department of Brain Repair and Rehabilitation, University College London Institute of Neurology, London, UK.
  • 6 Department of Medical Physics & Biomedical Engineering, University College London Faculty of Engineering Sciences, London, UK.
  • 7 Department of Psychiatry, University of Cambridge, Cambridge, UK.
  • 8 FMRIB Centre, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.
  • 9 Wellcome Trust Centre for Neuroimaging, UCL Institute of Neurology, London, UK.
Type
Published Article
Journal
Journal of Neurology Neurosurgery & Psychiatry
Publisher
BMJ
Publication Date
Nov 01, 2017
Volume
88
Issue
11
Pages
908–916
Identifiers
DOI: 10.1136/jnnp-2016-314978
PMID: 28473626
Source
Medline
Keywords
License
Unknown

Abstract

Pathologically distinct dementias exhibit characteristic patterns of regional volume loss compared with controls and other dementias. Voxelwise differences identified in these cohorts highlight imaging signatures that may aid in the differentiation of dementia subtypes during life. The results of this study are available for further examination via NeuroVault (http://neurovault.org/collections/ADHMHOPN/).

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