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Patterned iridium oxide film as neural electrode interface: Biocompatibility and improved neurite outgrowth with electrical stimulation.

Authors
  • Chen, Cen1
  • Ruan, Shichao2
  • Bai, Xue2
  • Lin, Chenming2
  • Xie, Chungang2
  • Lee, In-Seop3
  • 1 College of Life Sciences and Medicine, Zhejiang Sci-Tech University, Hangzhou 310018, PR China; School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou 325035, PR China; Institute of Natural Sciences, Yonsei University, Seoul 03722, Republic of Korea. , (China)
  • 2 College of Life Sciences and Medicine, Zhejiang Sci-Tech University, Hangzhou 310018, PR China. , (China)
  • 3 Institute of Natural Sciences, Yonsei University, Seoul 03722, Republic of Korea. Electronic address: [email protected] , (North Korea)
Type
Published Article
Journal
Materials science & engineering. C, Materials for biological applications
Publication Date
Oct 01, 2019
Volume
103
Pages
109865–109865
Identifiers
DOI: 10.1016/j.msec.2019.109865
PMID: 31349419
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Iridium (Ir) thin film was deposited on patterned titanium substrate by direct-current (DC) magnetron sputtering, and then activated in sulfuric acid (H2SO4) through repetitive potential sweeps to form iridium oxide (IrOx) as neural electrode interface. The resultant IrOx film showed a porous and open morphology with aligned microstructure, exhibited superior electrochemical performance and excellent stability. The IrOx film supported neural stem cells (NSCs) attachment, proliferation and improved processes without causing toxicity. The patterned IrOx films offered a unique system to investigate the synergistic effects of topographical cue and electrical stimulation on neurite outgrowth. Electrical stimulation, when applied through patterned IrOx films, was found to further increase the neurite extension of neuron-like cells and significantly reorient the neurite alignment towards to the direction of stimulation. These results indicate that IrOx film, as electrode-tissue interface is highly stable and biocompatible with excellent electrochemical properties. Copyright © 2019 Elsevier B.V. All rights reserved.

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