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Patients with systemic sclerosis present increased DNA damage differentially associated with DNA repair gene polymorphisms.

Authors
  • Palomino, Gustavo Martelli
  • Bassi, Carmen L
  • Wastowski, Isabela J
  • Xavier, Danilo J
  • Lucisano-Valim, Yara M
  • Crispim, Janaina C O
  • Rassi, Diane M
  • Marques-Neto, Joao F
  • Sakamoto-Hojo, Elza T
  • Moreau, Philippe
  • Sampaio-Barros, Percival D
  • Donadi, Eduardo A
Type
Published Article
Journal
The Journal of rheumatology
Publication Date
Mar 01, 2014
Volume
41
Issue
3
Pages
458–465
Identifiers
DOI: 10.3899/jrheum.130376
PMID: 24488411
Source
Medline
Keywords
License
Unknown

Abstract

These results corroborate the presence of genomic instability in SSc peripheral blood cells, as evaluated by increased DNA damage, and show that polymorphic sites of the XRCC1 and XRCC4 DNA repair genes may differentially influence DNA damage and the development of autoantibodies.

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