Affordable Access

deepdyve-link
Publisher Website

Patients with dyspepsia have impaired mucosal integrity both in the duodenum and jejunum: in vivo assessment of small bowel mucosal integrity using baseline impedance.

Authors
  • Nakagawa, Kenichiro1, 2
  • Hara, Ken1, 3
  • Fikree, Asma1
  • Siddiqi, Shahab4
  • Woodland, Philip1
  • Masamune, Atsushi2
  • Aziz, Qasim1
  • Sifrim, Daniel1
  • Yazaki, Etsuro5
  • 1 Wingate Institute of Neurogastroenterology, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, 26 Ashfield Street, Whitechapel, London, E1 AJ, UK.
  • 2 Division of Gastroenterology, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi, Aobaku, Sendai, 980-8574, Japan. , (Japan)
  • 3 Division of Gastroenterology, Hyogo College of Medicine, 1-1 Mukogawacho, Nishinomiya, 663-8501, Hyogo, Japan. , (Japan)
  • 4 Division of General Surgery, Broomfield Hospital, Court Rd, Broomfield, Chelmsford, CM1 7ET, UK.
  • 5 Wingate Institute of Neurogastroenterology, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, 26 Ashfield Street, Whitechapel, London, E1 AJ, UK. [email protected]
Type
Published Article
Journal
Journal of gastroenterology
Publication Date
Mar 01, 2020
Volume
55
Issue
3
Pages
273–280
Identifiers
DOI: 10.1007/s00535-019-01614-5
PMID: 31468184
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Recent studies reported that impaired proximal duodenal mucosa, assessed by duodenal biopsy, could play an important role in the development of dyspeptic symptoms. The aims of this study were (a) to develop a method to measure "in vivo" duodenal and jejunal baseline impedance (BI) and (b) to assess small bowel mucosal integrity in patients with functional dyspepsia (FD) and healthy controls (HC). We recruited 16 patients with FD and 15 HC. All subjects underwent ambulatory duodeno-jejunal manometry combined with impedance (HRM/Z), BI were determined by measuring impedance immediately after the passage of nocturnal migrating motor complex (MMC) phase IIIs. The number of MMC phase IIIs in FD was significantly lower than that in HC (2.6 ± 1.4 vs 4.8 ± 1.7, p < 0.001). The BI in patients was significantly lower than that in HC in D1(164.2 ± 59.8 Ω in FD and 243.1 ± 40.5 Ω in HC, p = 0.0061), D2 (191.2 ± 34.1 and 256.5 ± 91.4 Ω, p = 0.01), D3 (214.0 ± 76.9 and 278.1 ± 45.3 Ω, p = 0.009), D4 (270.8 ± 54.2 and 351.8 ± 50.2 Ω, p < 0.001), and J1 (312.2 ± 55.4 and 379.3 ± 38.3 Ω, p = 0.001). This is the first study reporting the duodenal and jejunal BI in vivo. The results have shown significantly lowered BI in the proximal small intestine in patients with FD compared to HC. Furthermore it suggests that measurements of small bowel BI could be used as a biomarker for diagnosis and follow up of patients with FD.

Report this publication

Statistics

Seen <100 times