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Patients with chronic hepatitis C express a high percentage of CD4+CXCR5+ T follicular helper cells

Authors
  • Feng, Junyan1
  • Hu, Xiaoli2, 3
  • Guo, Hui1
  • Sun, Xiguang1
  • Wang, Juan1
  • Xu, Lijun1
  • Jiang, Zhenyu1
  • Xu, Bingchuan1
  • Niu, Junqi3
  • Jiang, Yanfang1
  • 1 Jilin University, Department of Central Laboratory, The Second Part of First Hospital, Changchun, 130032, China , Changchun (China)
  • 2 Heilongjiang Province Hospital, Department of Infection, Harbin, China , Harbin (China)
  • 3 Jilin University, Department of Hepatology, First Hospital, Changchun, China , Changchun (China)
Type
Published Article
Journal
Journal of Gastroenterology
Publisher
Springer Japan
Publication Date
Mar 17, 2012
Volume
47
Issue
9
Pages
1048–1056
Identifiers
DOI: 10.1007/s00535-012-0568-1
Source
Springer Nature
Keywords
License
Yellow

Abstract

BackgroundT follicular helper (TFH) cells are a subpopulation of T-helper cells which regulate humoral immune responses. The role of TFH cells in viral infection is unclear. This study examined the possible involvement of CD4+CXCR5+ TFH cells in chronic hepatitis C (HCV) infection.MethodsThe percentages of peripheral blood CD4+CXCR5+ TFH cells, inducible T-cell costimulator cells, and/or programmed death 1-positive CD4+CXCR5+ TFH cells in 39 HCV-infected patients, 12 patients with spontaneously resolved HCV infection (SR-HCV), and 12 healthy controls were characterized by flow cytometry analysis. The subjects’ serum HCV RNA loads and alanine aminotransferase and aspartate aminotransferase levels were measured. The potential association of the percentage of peripheral CD4+CXCR5+ TFH cells with clinical data was analyzed.ResultsHigher percentages of peripheral blood CD4+CXCR5+ TFH cells were found in SR-HCV and HCV-infected patients as compared with healthy controls. Interestingly, a statistically significant negative correlation was found between the percentage of CD4+CXCR5+ TFH cells and the HCV RNA load.ConclusionsThese data suggest that CD4+CXCR5+ TFH cells may participate in HCV-related immune responses. Increased TFH cells in peripheral blood may help to control HCV infection.

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