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Patient-specific computational modeling of keratoconus progression and differential responses to collagen cross-linking.

Authors
  • Roy, Abhijit Sinha
  • Dupps, William J Jr
Type
Published Article
Journal
Investigative Ophthalmology & Visual Science
Publisher
Association for Research in Vision and Ophthalmology (ARVO)
Publication Date
Jan 01, 2011
Volume
52
Issue
12
Pages
9174–9187
Identifiers
DOI: 10.1167/iovs.11-7395
PMID: 22039252
Source
Medline
License
Unknown

Abstract

Progressive hyperelastic weakening of a cornea with subclinical KC produced topographic features of manifest KC. The clinical phenomenon of topographic flattening after CXL was replicated. The magnitude and higher-order optics of this response depended on IOP and the spatial distribution of stiffening relative to the cone location. Smaller diameter simulated treatments centered on the cone provided greater reductions in curvature and HOA than a standard broad-beam CXL pattern.

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