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Patient ancestry significantly contributes to molecular heterogeneity of systemic lupus erythematosus

Authors
  • Catalina, Michelle D.1, 2
  • Bachali, Prathyusha1
  • Yeo, Anthony E.3
  • Geraci, Nicholas S.1
  • Petri, Michelle A.4
  • Grammer, Amrie C.1
  • Lipsky, Peter E.1
  • 1 AMPEL BioSolutions LLC & RILITE Research Institute, Charlottesville, Virginia, USA.
  • 2 EMD Serono Research & Development Institute, Billerica, Massachusetts, USA.
  • 3 Yeo Analytics LLC, Jersey City, New Jersey.
  • 4 Division of Rheumatology, School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA.
Type
Published Article
Journal
JCI Insight
Publisher
American Society for Clinical Investigation
Publication Date
Aug 06, 2020
Volume
5
Issue
15
Identifiers
DOI: 10.1172/jci.insight.140380
PMID: 32759501
PMCID: PMC7455079
Source
PubMed Central
Keywords
License
Unknown
External links

Abstract

Transcriptional profiling of lupus patients and healthy controls reveals ancestry-related differences and transcriptional heterogeneity among lupus patients.

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