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Pathways to improving skin regeneration.

Authors
  • 1
Type
Published Article
Journal
Expert Reviews in Molecular Medicine
1462-3994
Publisher
Cambridge University Press
Publication Date
Volume
7
Issue
20
Pages
1–14
Identifiers
PMID: 16179092
Source
Medline

Abstract

A significant proportion of the human population suffers from some form of skin disorder, whether it be from burn injury or inherited skin anomalies. The ideal treatment for skin disorders would be to regrow skin tissue from stem cells residing in the individual patient's skin. Locating these adult stem cells and elucidating the molecules involved in orchestrating the production of new skin cells are important steps in devising more-efficient methods of skin production and wound healing via the ex vivo expansion of patient keratinocytes in culture. This review focuses on the structure of the skin, the identification of skin stem cells, and the role of Notch, Wnt and Hedgehog signalling cascades in regulating the fate of epidermal stem cells.

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