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Pathways to improving skin regeneration.

Authors
  • Adolphe, Christelle1
  • Wainwright, Brandon
  • 1 Institute for Molecular Bioscience, Queensland Bioscience Precinct, Building 80, Services Road, University of Queensland, St Lucia, 4072, Brisbane, Queensland, Australia. [email protected]
Type
Published Article
Journal
Expert Reviews in Molecular Medicine
Publisher
Cambridge University Press
Publication Date
Sep 23, 2005
Volume
7
Issue
20
Pages
1–14
Identifiers
PMID: 16179092
Source
Medline
License
Unknown

Abstract

A significant proportion of the human population suffers from some form of skin disorder, whether it be from burn injury or inherited skin anomalies. The ideal treatment for skin disorders would be to regrow skin tissue from stem cells residing in the individual patient's skin. Locating these adult stem cells and elucidating the molecules involved in orchestrating the production of new skin cells are important steps in devising more-efficient methods of skin production and wound healing via the ex vivo expansion of patient keratinocytes in culture. This review focuses on the structure of the skin, the identification of skin stem cells, and the role of Notch, Wnt and Hedgehog signalling cascades in regulating the fate of epidermal stem cells.

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