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Paths to stemness: building the ultimate antitumour T cell.

Authors
  • Gattinoni, Luca
  • Klebanoff, Christopher A
  • Restifo, Nicholas P
Type
Published Article
Journal
Nat Rev Cancer
Publication Date
Oct 01, 2012
Volume
12
Issue
10
Pages
671–684
Identifiers
DOI: 10.1038/nrc3322
PMID: 22996603
Source
Medline
License
Unknown

Abstract

Stem cells are defined by the ability to self-renew and to generate differentiated progeny, qualities that are maintained by evolutionarily conserved pathways that can lead to cancer when deregulated. There is now evidence that these stem cell-like attributes and signalling pathways are also shared among subsets of mature memory T lymphocytes. We discuss how using stem cell-like T cells can overcome the limitations of current adoptive T cell therapies, including inefficient T cell engraftment, persistence and ability to mediate prolonged immune attack. Conferring stemness to antitumour T cells might unleash the full potential of cellular therapies.

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