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Pathophysiology of exercise heart rate recovery: a comprehensive analysis.

Authors
  • Pierpont, Gordon L1
  • Adabag, Selcuk
  • Yannopoulos, Demetri
  • 1 Minneapolis Veterans Administration Medical Center, Minneapolis, MN 55417, USA. [email protected]
Type
Published Article
Journal
Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc
Publication Date
Mar 01, 2013
Volume
18
Issue
2
Pages
107–117
Identifiers
DOI: 10.1111/anec.12061
PMID: 23530480
Source
Medline
License
Unknown

Abstract

Expanded use of exercise heart rate recovery (HRR) has renewed interest in the pathophysiology of heart rate control. This study uses basic physiologic principles to construct a unique model capable of describing the full time course of sympathetic and parasympathetic activity during HRR. The model is tested in a new study of 22 diverse subjects undergoing both maximal and submaximal treadmill exercise. Based on this analysis, prolongation of HRR involves changes within the sinus node, changes in sympathetic function, in parasympathetic function, and in the central mechanisms regulating autonomic balance. The methods may provide unique insight into alterations in autonomic control in health and disease.

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