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Pathophysiology of Dysphagia in Eosinophilic Esophagitis: Causes, Consequences, and Management

Authors
  • Young, Edward
  • Philpott, Hamish
Type
Published Article
Journal
Digestive Diseases and Sciences
Publisher
Springer-Verlag
Publication Date
Mar 01, 2022
Volume
67
Issue
4
Pages
1101–1115
Identifiers
DOI: 10.1007/s10620-022-07419-6
PMID: 35230577
PMCID: PMC8976791
Source
PubMed Central
Keywords
Disciplines
  • Invited Review
License
Unknown

Abstract

Eosinophilic esophagitis (EoE) is a leading cause of food bolus impaction in children and adults. The mechanism of dysphagia in EoE, particularly non-obstructive dysphagia, remains incompletely understood. While fibrostenotic processes appear to be critical in the development of dysphagia, somatosensory dysfunction and dysmotility also contribute. This review considers potential mechanisms of dysphagia and evaluates the utility of current and future treatment strategies in this context.

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