Affordable Access

[Pathophysiologic programming of cell death].

Authors
  • Dobryszycka, W
Type
Published Article
Journal
Postȩpy higieny i medycyny doświadczalnej
Publication Date
Jan 01, 1998
Volume
52
Issue
5
Pages
423–444
Identifiers
PMID: 9857670
Source
Medline
License
Unknown

Abstract

In multicellular organisms homeostasis depends on a balance between cell proliferation and cell death. In this review principles of the physiology of programmed cell death (apoptosis), i.e. biochemical features, involved genes and proteolytic enzymes, are described. Alterations in apoptosis contribute to the pathogenesis of a number of human diseases, including cancer, viral infections, inflammation, hematopoietic and immunological system defects (e.g. AIDS), neurodegenerative disorders. Specific effect on regulation of apoptosis might lead to new possibilities for treatment. Methods of quantitative determinations of apoptosis are discussed.

Report this publication

Statistics

Seen <100 times