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Pathomechanisms in schwannoma development and progression

Authors
  • Helbing, Dario-Lucas1, 2
  • Schulz, Alexander1, 3
  • Morrison, Helen1
  • 1 Fritz Lipmann Institute,
  • 2 Institute of Molecular Cell Biology, Jena University Hospital, Friedrich Schiller University Jena, 07745 Jena, Germany
  • 3 MVZ Human Genetics, 99084 Erfurt, Germany
Type
Published Article
Journal
Oncogene
Publisher
Nature Publishing Group UK
Publication Date
Jul 02, 2020
Volume
39
Issue
32
Pages
5421–5429
Identifiers
DOI: 10.1038/s41388-020-1374-5
PMID: 32616891
PMCID: PMC7410823
Source
PubMed Central
Keywords
License
Unknown

Abstract

Schwannomas are tumors of the peripheral nervous system, consisting of different cell types. These include tumorigenic Schwann cells, axons, macrophages, T cells, fibroblasts, blood vessels, and an extracellular matrix. All cell types involved constitute an intricate “tumor microenvironment” and play relevant roles in the development and progression of schwannomas. Although Nf2 tumor suppressor gene-deficient Schwann cells are the primary tumorigenic element and principle focus of current research efforts, evidence is accumulating regarding the contributory roles of other cell types in schwannoma pathology. In this review, we aim to provide an overview of intra- and intercellular mechanisms contributing to schwannoma formation. “Genes load the gun, environment pulls the trigger.” -George A. Bray

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