Affordable Access

deepdyve-link
Publisher Website

Pathology of COVID-19-associated acute kidney injury

Authors
  • Sharma, Purva1, 2
  • Ng, Jia H1
  • Bijol, Vanesa2, 3
  • Jhaveri, Kenar D1, 2
  • Wanchoo, Rimda1, 2
  • 1 Division of Kidney Diseases and Hypertension, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, USA , (United States)
  • 2 Glomerular Center at Northwell Health, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, USA , (United States)
  • 3 Department of Pathology, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, USA , (United States)
Type
Published Article
Journal
Clinical Kidney Journal
Publisher
Oxford University Press
Publication Date
Jan 24, 2021
Volume
14
Issue
Suppl 1
Identifiers
DOI: 10.1093/ckj/sfab003
PMID: 33796284
PMCID: PMC7929005
Source
PubMed Central
Keywords
Disciplines
  • AcademicSubjects/MED00340
License
Unknown

Abstract

Acute kidney injury (AKI) is common among hospitalized patients with coronavirus disease 2019 (COVID-19), with the occurrence of AKI ranging from 0.5% to 80%. An improved knowledge of the pathology of AKI in COVID-19 is crucial to mitigate and manage AKI and to improve the survival of patients who develop AKI during COVID-19. In this review, we summarize the published cases and case series of various kidney pathologies seen with COVID-19. Both live kidney biopsies and autopsy series suggest acute tubular injury as the most commonly encountered pathology. Collapsing glomerulopathy and thrombotic microangiopathy are other encountered pathologies noted in both live and autopsy tissues. Other rare findings such as anti-neutrophil cytoplasmic antibody vasculitis, anti-glomerular basement membrane disease and podocytopathies have been reported. Although direct viral infection of the kidney is possible, it is certainly not a common or even widespread finding reported at the time of this writing (November 2020).

Report this publication

Statistics

Seen <100 times