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Pathological calcification and replicating calcifying-nanoparticles: general approach and correlation.

Authors
  • Ciftçioğlu, Neva1
  • McKay, David S
  • 1 Astromaterials Research and Exploration Science [N.C., D.S.M.], National Aeronautics and Space Administration, Johnson Space Center, Houston, Texas 77058, USA. [email protected]
Type
Published Article
Journal
Pediatric Research
Publisher
Springer Nature
Publication Date
May 01, 2010
Volume
67
Issue
5
Pages
490–499
Identifiers
DOI: 10.1203/PDR.0b013e3181d476ce
PMID: 20094006
Source
Medline
License
Unknown

Abstract

Calcification, a phenomenon often regarded by pathologists little more than evidence of cell death, is becoming recognized to be important in the dynamics of a variety of diseases from which millions of beings suffer in all ages. In calcification, all that is needed for crystal formation to start is nidi (nuclei) and an environment of available dissolved components at or near saturation concentrations, along with the absence of inhibitors for crystal formation. Calcifying nanoparticles (CNP) are the first calcium phosphate mineral containing particles isolated from human blood and were detected in numerous pathologic calcification related diseases. Controversy and critical role of CNP as nidi and triggering factor in human pathologic calcification are discussed.

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