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Pathogenic roles of altered calcium channels and transporters in colon tumorogenesis.

Authors
  • Yang, Xiaoxu1
  • Lou, Jun1
  • Shan, Weixi1
  • Hu, Yanxia1
  • Du, Qian1
  • Liao, Qiushi1
  • Xie, Rui2
  • Xu, Jingyu3
  • 1 Department of Gastroenterology, Affiliated Hospital to Zunyi Medical University, Zunyi, Guizhou, 563003, PR China. , (China)
  • 2 Department of Gastroenterology, Affiliated Hospital to Zunyi Medical University, Zunyi, Guizhou, 563003, PR China. Electronic address: [email protected] , (China)
  • 3 Department of Gastroenterology, Affiliated Hospital to Zunyi Medical University, Zunyi, Guizhou, 563003, PR China. Electronic address: [email protected] , (China)
Type
Published Article
Journal
Life sciences
Publication Date
Dec 15, 2019
Volume
239
Pages
116909–116909
Identifiers
DOI: 10.1016/j.lfs.2019.116909
PMID: 31689439
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Cytosolic calcium [Ca2+]cyt signaling plays a critical role in the regulation of multiple cellular functions, and Ca2+ channels/transporters are important to regulate calcium homeostasis whose abnormality may contribute human tumorogenesis including colorectal cancer (CRC). In this review, we summarized and discussed the current knowledge on pathogenic roles of the altered [Ca2+]cyt and Ca2+ channels/transporters like SOCE, TRP channels, SERCA and Na+/Ca2+ exchangers in CRC tumorigenesis and progression. Understanding the detailed molecular mechanisms underlying the effects of [Ca2+]cyt on CRC is essential to develop Ca2+ channels/transporters as diagnostic and therapeutic targets. Targeting Ca2+ signaling for cancer therapy has become an emerging research area nowadays, although our knowledge about the roles of Ca2+ channels/transporters in tumorigenesis is still in the early stage, we still believe that they will act as novel preventive/therapeutic targets for CRC with potentially extensive clinical significance. Copyright © 2019 Elsevier Inc. All rights reserved.

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