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Pathogenic budding yeasts isolated outside of clinical settings.

Authors
  • Opulente, Dana A1, 2
  • Langdon, Quinn K1
  • Buh, Kelly V1
  • Haase, Max A B1, 2
  • Sylvester, Kayla1, 2
  • Moriarty, Ryan V1, 2
  • Jarzyna, Martin1
  • Considine, Samantha L1
  • Schneider, Rachel M1, 2
  • Hittinger, Chris Todd1, 2
  • 1 Laboratory of Genetics, Genome Center of Wisconsin, Wisconsin Energy Institute, J. F. Crow Institute for the Study of Evolution, University of Wisconsin-Madison, Madison, WI 53706, USA.
  • 2 DOE Great Lakes Bioenergy Research Center, University of Wisconsin-Madison, Madison, WI 53706, USA.
Type
Published Article
Journal
FEMS Yeast Research
Publisher
Oxford University Press
Publication Date
May 01, 2019
Volume
19
Issue
3
Identifiers
DOI: 10.1093/femsyr/foz032
PMID: 31076749
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Budding yeasts are distributed across a wide range of habitats, including as human commensals. However, under some conditions, these commensals can cause superficial, invasive, and even lethal infections. Despite their importance to human health, little is known about the ecology of these opportunistic pathogens, aside from their associations with mammals and clinical environments. During a survey of approximately 1000 non-clinical samples across the United States of America, we isolated 54 strains of budding yeast species considered opportunistic pathogens, including Candida albicans and Candida (Nakaseomyces) glabrata. We found that, as a group, pathogenic yeasts were positively associated with fruits and soil environments, whereas the species Pichia kudriavzevii (syn. Candida krusei syn. Issatchenkia orientalis) had a significant association with plants. Of the four species that cause 95% of candidiasis, we found a positive association with soil. These results suggest that pathogenic yeast ecology is more complex and diverse than is currently appreciated and raises the possibility that these additional environments could be a point of contact for human infections. © FEMS 2019.

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