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The pathogenesis of Perthes' disease.

Authors
  • Inoue, A
  • Freeman, M A
  • Vernon-Roberts, B
  • Mizuno, S
Type
Published Article
Journal
The Journal of bone and joint surgery. British volume
Publication Date
Nov 01, 1976
Volume
58-B
Issue
4
Pages
453–461
Identifiers
PMID: 1018031
Source
Medline
License
Unknown

Abstract

It has been shown that in the puppy, two infarcts separated by an interval of four weeks produce a disorder of long duration which results in flattening and broadening of the femoral head and which reproduces the radiological changes seen in Perthes' disease in man. The histological appearances produced by two infarcts are characteristic. In this study the histological appearance of fifty-seven femoral head biopsy specimens in Perthes' disease in man have been studied. In 51 per cent of hips histopathological changes characteristic of double infarction were present, and there were grounds for postulating that double infarction might eventually occur in all cases. The findings support the concept that the deformation of the femoral head and the chronicity of Perthes' disease in man may be due at least as much or even more to repeated episodes of infarction and the ensuing abnormalities of growth as to mechanical factors related to weight-bearing.

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