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Pathogenesis of hyperuricemia: recent advances.

Authors
  • Ghei, Manisha
  • Mihailescu, Mihaela
  • Levinson, Dennis
Type
Published Article
Journal
Current rheumatology reports
Publication Date
Jun 01, 2002
Volume
4
Issue
3
Pages
270–274
Identifiers
PMID: 12010614
Source
Medline
License
Unknown

Abstract

The literature on the pathogenesis of hyperuricemia have been limited to the discussion of metabolic syndromes associated with risk factors for atherosclerosis and hyperuricemia and the genetics of the juvenile form of hyperuricemic nephropathies. A few new mutations in the hypoxanthine-guanine phosphoribosyltransferase gene, which result in Lesch-Nyhan syndrome, have been described. In addition, some new insight has been gained in the renal handling of uric acid by the human kidney.

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