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Pathogenesis of caseous lymphadenitis in sheep and goats.

Authors
  • Batey, R G
Type
Published Article
Journal
Australian veterinary journal
Publication Date
Sep 01, 1986
Volume
63
Issue
9
Pages
269–272
Identifiers
PMID: 3800800
Source
Medline
License
Unknown

Abstract

The progress of caseous lymphadenitis in sheep and goats is described as involving primary wound infection, lymphatic and haematogenous dissemination, and secondary infection of lymph nodes and various visceral organs. This is followed by elimination or containment of infection, the latter being represented by the characteristic caseous lesions. Resistance to infection is complex involving components of both the specific and non-specific host response. The role of these in pathogenesis is discussed. Bacterial factors including the phospholipase exotoxin and cytotoxic lipid contribute to pathogenesis at a local level with little likelihood of systemic effect in the natural disease. In a disease such as caseous lymphadenitis, lesion site, size or number do not indicate severity of disease but rather, reflect the ability of the host to mount a cellular response to infection.

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