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The path(way) less traveled.

Authors
  • Abedi, Mehrdad1
  • Murphy, William J
  • 1 UNIVERSITY OF CALIFORNIA DAVIS SCHOOL OF MEDICINE.
Type
Published Article
Journal
Blood
Publisher
American Society of Hematology
Publication Date
Sep 19, 2013
Volume
122
Issue
12
Pages
1996–1997
Identifiers
DOI: 10.1182/blood-2013-07-516856
PMID: 24052539
Source
Medline
Language
English
License
Unknown

Abstract

In this issue of Blood, Mathewson et al characterized targeting a novel intracellular pathway with an agent known to induce potent antitumor effects but now also appears to potently suppress inflammatory responses by dendritic cells (DCs) and prevent graft-vs-host disease (GVHD). Identifying agents that can suppress GVHD yet not compromise graft-vs-tumor (GVT) effects remains a paramount goal in allogeneic hematopoietic stem cell transplantation (HSCT).

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