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Passive transfer of demyelination by experimental allergic neuritis serum.

Authors
  • Hahn, A F
  • Gilbert, J J
  • Feasby, T E
Type
Published Article
Journal
Acta neuropathologica
Publication Date
Jan 01, 1980
Volume
49
Issue
3
Pages
169–176
Identifiers
PMID: 7368896
Source
Medline
License
Unknown

Abstract

Serum from rabbits with experimental allergic neuritis (EAN) when injected into rat sciatic nerves produced rapidly evolving demyelination followed by remyelination. Myelinating and non-meylinating Schwann cells as well as myelin itself were damaged by 15 min after injection. Myelin degradation was well advanced prior to involvement by macrophages at 12 h. The demyelinating factor was myelin-specific and complement-dependent. The evidence suggests that the EAN antigen may reside in Schwann cell membranes as well as in myelin.

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