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PASSIVE TRANSFER OF THE ACTION OF FREUND'S ADJUVANT BY SERUM OF RABBITS INJECTED WITH THE ADJUVANT.

Authors
  • DAWE, D L
  • SEGRE, D
  • MYERS, W L
Type
Published Article
Journal
Science
Publisher
American Association for the Advancement of Science (AAAS)
Publication Date
Jun 04, 1965
Volume
148
Issue
3675
Pages
1345–1347
Identifiers
PMID: 14281719
Source
Medline
Keywords
License
Unknown

Abstract

Serum collected at intervals from rabbits treated with Freund's complete adjuvant was injected together with fluid diphtheria toxoid into recipient rabbits. Control rabbits received toxoid alone or toxoid mixed with serum of untreated donors. There was no antibody response in the controls or in recipients of serum obtained from donors 3 days after adjuvant treatment. Recipients of serum obtained from donors 1 to 9 weeks after adjuvant treatment responded with antibody formation. The magnitude of the response of recipients was correlated with the increase in gamma-globulin concentration in the serums of the corresponding donor rabbits. Passive transfer of adjuvant action indicates that a serum factor, possibly natural antibody, is partially responsible for the immunity-enhancing activity of Freund's adjuvant.

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