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[Participation of the thymus in controlling cytomedine activity].

Authors
  • Kalashnikov, S G
  • Kuznik, B I
  • Tsybikov, N N
Type
Published Article
Journal
Patologicheskaia fiziologiia i èksperimental'naia terapiia
Publication Date
Jan 01, 1989
Issue
1
Pages
57–60
Identifiers
PMID: 2717235
Source
Medline
License
Unknown

Abstract

The authors studied the effect of the thymus on the composition and biological activity of cytomedines--mediators of intercellular interactions contained in the tissues. Samples of the liver, muscle, and spleen of thymectomized rats lacked some components of the polypeptide system which were found in these organs of animals subjected to sham operation and castration. Thymalin injection restored the initial polypeptide pattern. The factors studied also differed in biological activity: polypeptide factors isolated from organs of animals which underwent a sham operation stimulated the immunity of thymectomized rats, peptides from organs of thymectomized animals, in contrast, did not possess this property.

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