Affordable Access

deepdyve-link
Publisher Website

The paraventricular nucleus of the hypothalamus - a potential target for integrative treatment of autonomic dysfunction.

Authors
  • Ferguson, Alastair V
  • Latchford, Kevin J
  • Samson, Willis K
Type
Published Article
Journal
Expert Opinion on Therapeutic Targets
Publisher
Informa UK (Taylor & Francis)
Publication Date
Jun 01, 2008
Volume
12
Issue
6
Pages
717–727
Identifiers
DOI: 10.1517/14728222.12.6.717
PMID: 18479218
Source
Medline
License
Unknown

Abstract

This review highlights data showing that individual afferent inputs (subfornical organ), signaling molecules (orexins, adiponectin), and interneurons (glutamate/GABA), all have the potential to influence (and thus coordinate) multiple PVN output pathways. We also highlight recent studies showing that modifications in this integrated circuitry may play significant roles in the pathology of diseases such as congestive heart failure and hypertension.

Report this publication

Statistics

Seen <100 times