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Paraoxonase 1 (PON1)-L55M among common variants in the coding region of the paraoxonase gene family may contribute to the glycemic control in type 2 diabetes.

Authors
  • Mahrooz, Abdolkarim1
  • Hashemi-Soteh, Mohammad Bagher2
  • Heydari, Masoud3
  • Boorank, Ruzbeh3
  • Ramazani, Fatemeh3
  • Mahmoudi, Ali3
  • Kianmehr, Anvarsadat4
  • Alizadeh, Ahad5
  • 1 Molecular and Cell Biology Research Center, Mazandaran University of Medical Sciences, Sari, Iran; Immunogenetics Research Center, Mazandaran University of Medical Sciences, Sari, Iran; Department of Clinical Biochemistry and Genetics, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran. Electronic address: [email protected] , (Iran)
  • 2 Immunogenetics Research Center, Mazandaran University of Medical Sciences, Sari, Iran; Department of Clinical Biochemistry and Genetics, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran. , (Iran)
  • 3 Department of Clinical Biochemistry and Genetics, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran. , (Iran)
  • 4 Department of Medical Biotechnology, Faculty of Advanced Medical Technologies, Golestan University of Medical Sciences, Gorgan, Iran. , (Iran)
  • 5 Department of Epidemiology and Reproductive Health, Reproductive Epidemiology Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran. Electronic address: [email protected] , (Iran)
Type
Published Article
Journal
Clinica chimica acta; international journal of clinical chemistry
Publication Date
May 19, 2018
Volume
484
Pages
40–46
Identifiers
DOI: 10.1016/j.cca.2018.05.037
PMID: 29782842
Source
Medline
Keywords
License
Unknown

Abstract

Sex should be considered a confounding variable in association studies on the variants PON1-Q192R and PON2-A148G in T2D. Patients sharing the 55 M allele were prone to having good glycemic control. Our findings provide genetic evidence that the PON1-L55M variant may be a factor contributing to glycemic control.

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