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Parallel in vivo experimental evolution reveals that increased stress resistance was key for the emergence of persistent tuberculosis bacilli

Authors
  • Allen, Aideen C.1
  • Malaga, Wladimir1
  • Gaudin, Cyril2, 3
  • Volle, Arnaud1
  • Moreau, Flavie1
  • Hassan, Ali1
  • Astarie-Dequeker, Catherine1
  • Peixoto, Antonio1
  • Antoine, Rudy2
  • Pawlik, Alexandre4
  • Frigui, Wafa4
  • Berrone, Céline1
  • Brosch, Roland4
  • Supply, Philip2
  • Guilhot, Christophe1
  • 1 Université de Toulouse, CNRS, UPS, Toulouse, France , Toulouse (France)
  • 2 Center for Infection and Immunity, Lille, France , Lille (France)
  • 3 Genoscreen, Lille, France , Lille (France)
  • 4 Unit for Integrated Mycobacterial Pathogenomics, CNRS UMR3525, Paris, France , Paris (France)
Type
Published Article
Journal
Nature Microbiology
Publisher
Nature Publishing Group UK
Publication Date
Jul 22, 2021
Volume
6
Issue
8
Pages
1082–1093
Identifiers
DOI: 10.1038/s41564-021-00938-4
Source
Springer Nature
Disciplines
  • article
License
Yellow

Abstract

In vivo experimental evolution of Mycobacterium canettii populations reveals enhanced persistence of evolved mutants due to resistance to host-derived stresses, providing insight into the emergence of persistent Mycobacterium tuberculosis.

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