Paradoxical action of penicillin G on Staphylococcus aureus: a time study of the effect of a zonal antibiotic concentration gradient on bacterial growth.
- Published Article
Antimicrobial agents and chemotherapy
- Publication Date
Sep 01, 1975
The killing rate of a zonal concentration gradient of penicillin G on Staphylococcus aureus was studied by using a previously described triple-layer technique, enzymatic inactivation of the antibiotic, and an automatic image analyzer. This gradient determines a target image, whose center is the reservoir of antibiotic (constituted by a paper disk containing 100 U of penicillin G) and whose successive concentric zones are: a zone of slow bactericidal activity (corresponding to high levels of penicillin G), a zone of maximal bactericidal activity (corresponding to optimal levels of penicillin G), and a zone of overgrowth situated in front of the antibiotic wave.
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The corresponding record at NLM can be accessed at https://www.ncbi.nlm.nih.gov/pubmed/1167041