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Paracetamol Treatment for Patent Ductus Arteriosus, an Apparent Association with Acute Hemolysis in Three Preterm Infants: Case Series

Authors
  • Bauer-Rusek, Sofia
  • Samra, Nava
  • Moore, Shiran Sara
  • Arnon, Shmuel
Type
Published Article
Journal
Neonatology
Publisher
S. Karger AG
Publication Date
Jun 21, 2022
Volume
119
Issue
4
Pages
530–534
Identifiers
DOI: 10.1159/000525128
PMID: 35728580
Source
Karger
Keywords
Disciplines
  • Novel Insights from Clinical Practice
License
Green
External links

Abstract

We report three preterm infants who were treated with paracetamol for hemodynamically significant patent ductus arteriosus and developed acute hemolysis. No other apparent cause of acute hemolysis was found during Neonatal Intensive Care Unit hospitalization. All three infants were born within 1 year. As this side effect of paracetamol has not been reported previously and many preterm infants receive paracetamol for PDA closure, we advocate awareness. We cannot be sure whether the hemolysis occurred due to an underlying cause that was augmented by paracetamol or whether the drug itself caused acute hemolysis in these preterm infants.

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