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Papulopustular drug eruption due to an epidermal growth factor receptor inhibitors, erlotinib and cetuximab.

Authors
  • Bragg, Jennifer
  • Pomeranz, Miriam Keltz
Type
Published Article
Journal
Dermatology online journal
Publication Date
Jan 01, 2007
Volume
13
Issue
1
Pages
1–1
Identifiers
PMID: 17511934
Source
Medline
License
Unknown

Abstract

Two patients receiving epidermal growth factor receptor inhibitors for cancer treatment developed papulopustular eruptions a few days after starting treatment. One patient is a 56-year-old man with metastatic lung cancer treated with erlotinib. Bacterial cultures of the nares and a pustule showed no growth. The eruption improved with a lowered dose of erlotinib and the application of topical clindamycin solution and triamcinolone cream. The other patient is a 53-year-old man with metastatic rectal cancer treated with cetuximab. Bacterial culture of a pustule grew Staphylococcus aureus, and a skin biopsy specimen showed a suppurative folliculitis. The eruption improved with a two-week course of oral antibiotics and the application of topical clindamycin solution and triamcinolone cream. A papulopustular eruption occurs in up to 90% of patients treated with epidermal growth factor receptor blocking agents and may correlate with a positive response to chemotherapy. Treatment options are based on anecdotal evidence and may include topical antibiotics, topical glucocorticoids, and oral antibiotics for secondary infection.

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