Affordable Access

Papillomavirus common antigen in Bowen's disease.

Authors
  • Grussendorf-Conen, E I
  • Giesen, M
Type
Published Article
Journal
Dermatologica
Publication Date
Jan 01, 1990
Volume
181
Issue
1
Pages
11–15
Identifiers
PMID: 2168322
Source
Medline
License
Unknown

Abstract

We studied 173 biopsies of histologically determined Bowen's disease and looked for the presence of papillomavirus antigen using immunoperoxidase staining. Fifty-nine of the lesions were located at the head, 49 at the extremities, 36 at the trunk and 29 originated from the genital region. Papillomavirus capsid antigen could be clearly identified in 39 (22.5%) cases. Eleven (38%) of the 29 lesions located on genital skin were positive for papillomavirus capsid antigen while 28 (19.4%) of the 144 biopsies from other skin regions contained viral antigen. Our findings are suggestive of an etiologic relationship between the virus and this dermatosis which represents a special variant of squamous cell carcinoma. They indicate that human papillomaviruses may play an important role in the development of cutaneous malignancies.

Report this publication

Statistics

Seen <100 times