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Papillomatous melanocytic nevi: an estrogen related phenomenon.

Authors
  • Morgan, M B
  • Raley, B A
  • Vannarath, R L
  • Lightfoot, S L
  • Everett, M A
Type
Published Article
Journal
Journal of cutaneous pathology
Publication Date
Oct 01, 1995
Volume
22
Issue
5
Pages
446–449
Identifiers
PMID: 8594078
Source
Medline
License
Unknown

Abstract

A prospective two-month epidemiologic and histologic study of all melanocytic nevi biopsied (n = 434) at the University of Oklahoma Health Center was undertaken. Melanocytic nevi with papillomatous features (PAP) (n = 50) were found to occur predominantly in females (females = 44, males = 6; p < 0.01 adjusted for sex distribution of all melanocytic nevi). Immunohistochemical analysis of melanocytic nevi revealed concordance between PAP and intracytoplasmic nevocellular staining for estrogen-inducible pS2 protein. Melanocytic nevi without papillomatous features failed to stain for pS2 protein. These results suggest a hormone responsiveness exclusive of patient sex which may influence the pathogenesis of these distinctive melanocytic nevi.

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