Affordable Access

Access to the full text

A panel of protein kinase high expression is associated with postoperative recurrence in cholangiocarcinoma

Authors
  • Padthaisong, Sureerat1
  • Thanee, Malinee2, 2
  • Namwat, Nisana1, 2, 2
  • Phetcharaburanin, Jutarop1, 2, 2
  • Klanrit, Poramate1, 2, 2
  • Khuntikeo, Narong2, 2, 2
  • Titapun, Attapol2, 2, 2
  • Loilome, Watcharin1, 2, 2
  • 1 Khon Kaen University, 123 Mittraparp Road, Muang District, Khon Kaen, 40002, Thailand , Khon Kaen (Thailand)
  • 2 Khon Kaen University, Khon Kaen, 40002, Thailand , Khon Kaen (Thailand)
Type
Published Article
Journal
BMC Cancer
Publisher
Springer (Biomed Central Ltd.)
Publication Date
Feb 24, 2020
Volume
20
Issue
1
Identifiers
DOI: 10.1186/s12885-020-6655-4
Source
Springer Nature
Keywords
License
Green

Abstract

BackgroundCancer recurrence is one of the most concerning clinical problems of cholangiocarcinoma (CCA) patients after treatment. However, an identification of predictive factor on Opisthorchis viverrini (OV)-associated CCA recurrence is not well elucidated. In the present study, we aimed to investigate the correlation of twelve targeted protein kinases with CCA recurrence.MethodsTwelve protein kinases, epidermal growth factor receptor (EGFR), human epidermal growth factor receptor 2, 3, 4 (HER2, HER3, HER4), vascular endothelial growth factor receptor 3 (VEGFR3), vascular endothelial growth factor-C (VEGF-C), erythropoietin-producing hepatocellular carcinoma receptor type-A3 (EphA3), EphrinA1, phosphor-serine/threonine kinase 1 (p-Akt1), serine/threonine kinase 1 (Akt1), beta-catenin and protein Wnt5a (Wnt5a) were examined using immunohistochemistry. Pre-operative serum tumor markers, CA19–9 and CEA were also investigated.ResultsAmong twelve protein kinases, EGFR, HER4, and EphA3 were associated with tumor recurrence status, recurrence-free survival (RFS) and overall survival (OS). Multivariate cox regression demonstrated that EGFR, HER4, EphA3 or the panel of high expression of these proteins was an independent prognostic factor for tumor recurrence. The combination of high expression of these proteins with a high level of CA19–9 could improve the predictive ability on tumor recurrence. Moreover, the patients were stratified more accurately when analyzed using the combination of high expression of these proteins with primary tumor (T) or lymph node metastasis (N) status.ConclusionEGFR, HER4, EphA3 or the panel of high expression of these proteins is an independent prognostic factor for post-operative CCA recurrence.

Report this publication

Statistics

Seen <100 times