Affordable Access

deepdyve-link
Publisher Website

Pancreatic perfusion and its response to glucose as measured by simultaneous PET/MRI.

Authors
  • Espes, Daniel1, 2
  • Manell, Elin3
  • Rydén, Anneli3
  • Carlbom, Lina4
  • Weis, Jan5
  • Jensen-Waern, Marianne3
  • Jansson, Leif1
  • Eriksson, Olof6
  • 1 Department of Medical Cell Biology, Uppsala University, 751 23, Uppsala, Sweden. , (Sweden)
  • 2 Department of Medical Sciences, Uppsala University, 751 83, Uppsala, Sweden. , (Sweden)
  • 3 Department of Clinical Sciences, Swedish University of Agricultural Sciences, Uppsala, Sweden. , (Sweden)
  • 4 Department of Surgical Sciences, Uppsala University, 751 83, Uppsala, Sweden. , (Sweden)
  • 5 Department of Medical Physics, Uppsala University Hospital, 751 83, Uppsala, Sweden. , (Sweden)
  • 6 Science for Life Laboratory, Department of Medicinal Chemistry, Uppsala University, Dag Hammarskjölds väg 14C, 3tr, 751 83, Uppsala, Sweden. [email protected] , (Sweden)
Type
Published Article
Journal
Acta diabetologica
Publication Date
Oct 01, 2019
Volume
56
Issue
10
Pages
1113–1120
Identifiers
DOI: 10.1007/s00592-019-01353-2
PMID: 31028528
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Perfusion of the pancreas and the islets of Langerhans is sensitive to physiological stimuli and is dysregulated in metabolic disease. Pancreatic perfusion can be assessed by both positron emission tomography (PET) and magnetic resonance imaging (MRI), but the methods have not been directly compared or benchmarked against the gold-standard microsphere technique. Pigs (n = 4) were examined by [15O]H2O PET and intravoxel incoherent motion (IVIM) MRI technique simultaneously using a hybrid PET/MRI scanner. The pancreatic perfusion was measured both at basal conditions and after intravenous (IV) administration of up to 0.5 g/kg glucose. Pancreatic perfusion increased by 35%, 157%, and 29% after IV 0.5 g/kg glucose compared to during basal conditions, as assessed by [15O]H2O PET, IVIM MRI, and microspheres, respectively. There was a correlation between pancreatic perfusion as assessed by [15O]H2O PET and IVIM MRI (r = 0.81, R2 = 0.65, p < 0.01). The absolute quantification of pancreatic perfusion (ml/min/g) by [15O]H2O PET was within a 15% error of margin of the microsphere technique. Pancreatic perfusion by [15O]H2O PET was in agreement with the microsphere technique assessment. The IVIM MRI method has the potential to replace [15O]H2O PET if the pancreatic perfusion is sufficiently large, but not when absolute quantitation is required.

Report this publication

Statistics

Seen <100 times