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Pancreatic epithelial cells can be converted into insulin-producing cells by GLP-1 in conjunction with virus-mediated gene transfer of pdx-1.

Authors
  • Koizumi, Masayuki
  • Doi, Ryuichiro
  • Fujimoto, Koji
  • Ito, Daisuke
  • Toyoda, Eiji
  • Mori, Tomohiko
  • Kami, Kazuhiro
  • Kawaguchi, Yoshiya
  • Gittes, George K
  • Imamura, Masayuki
Type
Published Article
Journal
Surgery
Publisher
Elsevier
Publication Date
Aug 01, 2005
Volume
138
Issue
2
Pages
125–133
Identifiers
PMID: 16153418
Source
Medline
License
Unknown

Abstract

GLP-1 and pdx-1 work together to induce insulin-producing cells from IMPE cells, which bear unique characteristics of pancreatic ductal cells. The results suggest that GLP-1 may be another important determiner of pancreatic endocrine differentiation as is pdx-1.

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