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Pancreatic elastase activates pulmonary nuclear factor kappa B and inhibitory kappa B, mimicking pancreatitis-associated adult respiratory distress syndrome.

Authors
Type
Published Article
Journal
Surgery
0039-6060
Publisher
Elsevier
Publication Date
Volume
128
Issue
2
Pages
225–231
Identifiers
PMID: 10922996
Source
Medline

Abstract

Pancreatic elastase induces cytokine-mediated lung injury and this pathway involves the NF-kappaB second messenger system, further supporting elastase as a factor linking pancreatic inflammation to systemic illness during severe acute pancreatitis.

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